A large part of the literature on the mathematical modelling of infectious disease transmission consists precisely of relaxing the above assumptions and some others by constructing appropriate models and examining how the models behavior changes as the model assumptions are modified 6 7 8. Several groups of investigators modeled the human immunodeficiency virus hiv host dynamics as reviewed by wodarz and nowak 50 who by themselves use a basic model of virus infection and replication to study hiv dynamics and to measure crucial parameters that lead to a new understanding of the disease process 51 simulation studies have shown . Infectious disease modelling is a peer reviewed open access journal aiming to promote research working to interface mathematical modelling infection. This is one reason why computer models are gaining popularity perhaps the best sign for this increase in popularity is the diversity of disease models that can be found in the literature another sign for the popularity is the need for proper modeling guidelines for general disease modeling and specifically for diabetes . Inspired by a collaborative and multidisciplinary effort from the scientific community idms innovative software tools provide a quantitative and analytical means to model infectious disease tools are provided to the scientific community to accelerate the exploration of disease eradication through the use of computational modeling
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